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A mutant light chain ferritin that causes neurodegeneration has enhanced propensity toward oxidative damage
Intracellular inclusion bodies (IBs) containing ferritin and iron accumulation are hallmarks of hereditary ferritinopathy (HF). This neurodegenerative disease is caused by mutations in the coding sequence of the ferritin light chain (FTL) gene that generate FTL polypeptides with a C-terminus that is...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3341510/ https://ncbi.nlm.nih.gov/pubmed/22348978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2012.02.015 |
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