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A mutant light chain ferritin that causes neurodegeneration has enhanced propensity toward oxidative damage

Intracellular inclusion bodies (IBs) containing ferritin and iron accumulation are hallmarks of hereditary ferritinopathy (HF). This neurodegenerative disease is caused by mutations in the coding sequence of the ferritin light chain (FTL) gene that generate FTL polypeptides with a C-terminus that is...

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Bibliografiske detaljer
Main Authors: Baraibar, Martin A., Barbeito, Ana G., Muhoberac, Barry B., Vidal, Ruben
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341510/
https://ncbi.nlm.nih.gov/pubmed/22348978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2012.02.015
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