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Endogenous mitochondrial oxidative stress in MnSOD deficient mouse embryonic fibroblasts promotes mitochondrial DNA glycation
The accumulation of somatic mutations in mitochondrial DNA (mtDNA) induced by reactive oxidative species (ROS) is regarded as a major contributor of aging and age-related degenerative diseases. ROS has also been shown to facilitate the formation of certain advanced glycation end-products in proteins...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3341489/ https://ncbi.nlm.nih.gov/pubmed/22370091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2012.02.021 |
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