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Structure of p73 DNA-binding domain tetramer modulates p73 transactivation

The transcription factor p73 triggers developmental pathways and overlaps stress-induced p53 transcriptional pathways. How p53-family response elements determine and regulate transcriptional specificity remains an unsolved problem. In this work, we have determined the first crystal structures of p73...

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Detalhes bibliográficos
Main Authors: Ethayathulla, Abdul S., Tse, Pui-Wah, Monti, Paola, Nguyen, Sonha, Inga, Alberto, Fronza, Gilberto, Viadiu, Hector
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341074/
https://ncbi.nlm.nih.gov/pubmed/22474346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115463109
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