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Predictable and tunable half-life extension of therapeutic agents by controlled chemical release from macromolecular conjugates
Conjugation to macromolecular carriers is a proven strategy for improving the pharmacokinetics of drugs, with many stable polyethylene glycol conjugates having reached the market. Stable conjugates suffer several limitations: loss of drug potency due to conjugation, confining the drug to the extrace...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3341049/ https://ncbi.nlm.nih.gov/pubmed/22474378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117147109 |
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