Structural and mechanistic analysis of the membrane-embedded glycosyltransferase WaaA required for lipopolysaccharide synthesis

WaaA is a key enzyme in the biosynthesis of LPS, a critical component of the outer envelope of Gram-negative bacteria. Embedded in the cytoplasmic face of the inner membrane, WaaA catalyzes the transfer of 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) to the lipid A precursor of LPS. Here we present cry...

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Detalhes bibliográficos
Main Authors: Schmidt, Helgo, Hansen, Guido, Singh, Sonia, Hanuszkiewicz, Anna, Lindner, Buko, Fukase, Koichi, Woodard, Ronald W., Holst, Otto, Hilgenfeld, Rolf, Mamat, Uwe, Mesters, Jeroen R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341020/
https://ncbi.nlm.nih.gov/pubmed/22474366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119894109
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