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Ligand structural motifs can decouple glucocorticoid receptor transcriptional activation from target promoter occupancy
Glucocorticoid (GC) induction of the tyrosine aminotransferase (TAT) gene by the glucocorticoid receptor (GR) is a classic model used to investigate steroid-regulated gene expression. Classic studies analyzing GC-induction of the TAT gene demonstrated that despite having very high affinity for GR, s...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3340612/ https://ncbi.nlm.nih.gov/pubmed/22465009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2012.03.084 |
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