The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine

BACKGROUND: Relapse to cocaine-seeking has been linked with low glutamate in the nucleus accumbens core (NAcore) causing potentiation of synaptic glutamate transmission from prefrontal cortex (PFC) afferents. Systemic N-acetylcysteine (NAC) has been shown to restore glutamate homeostasis, reduce rel...

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Autores principales: Kupchik, Yonatan M., Moussawi, Khaled, Tang, Xing-Chun, Wang, Xiusong, Kalivas, Benjamin C., Kolokithas, Rosalia, Ogburn, Katelyn B., Kalivas, Peter W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340445/
https://ncbi.nlm.nih.gov/pubmed/22137594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2011.10.024
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