Allele Specific Locked Nucleic Acid Quantitative PCR (ASLNAqPCR): An Accurate and Cost-Effective Assay to Diagnose and Quantify KRAS and BRAF Mutation

The use of tyrosine kinase inhibitors (TKIs) requires the testing for hot spot mutations of the molecular effectors downstream the membrane-bound tyrosine kinases since their wild type status is expected for response to TKI therapy. We report a novel assay that we have called Allele Specific Locked...

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Hlavní autoři: Morandi, Luca, de Biase, Dario, Visani, Michela, Cesari, Valentina, De Maglio, Giovanna, Pizzolitto, Stefano, Pession, Annalisa, Tallini, Giovanni
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340405/
https://ncbi.nlm.nih.gov/pubmed/22558339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036084
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