Promoter methylation analysis of O6-methylguanine-DNA methyltransferase in glioblastoma: detection by locked nucleic acid based quantitative PCR using an imprinted gene (SNURF) as a reference

BACKGROUND: Epigenetic silencing of the MGMT gene by promoter methylation is associated with loss of MGMT expression, diminished DNA-repair activity and longer overall survival in patients with glioblastoma who, in addition to radiotherapy, received alkylating chemotherapy with carmustine or temozol...

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Detalhes bibliográficos
Main Authors: Morandi, Luca, Franceschi, Enrico, de Biase, Dario, Marucci, Gianluca, Tosoni, Alicia, Ermani, Mario, Pession, Annalisa, Tallini, Giovanni, Brandes, Alba
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Technical Advance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843669/
https://ncbi.nlm.nih.gov/pubmed/20167086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-48
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