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Novel ATP-Independent RNA Annealing Activity of the Dengue Virus NS3 Helicase

The flavivirus nonstructural protein 3 (NS3) bears multiple enzymatic activities and represents an attractive target for antiviral intervention. NS3 contains the viral serine protease at the N-terminus and ATPase, RTPase, and helicase activities at the C-terminus. These activities are essential for...

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Detalhes bibliográficos
Main Authors: Gebhard, Leopoldo G., Kaufman, Sergio B., Gamarnik, Andrea V.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340334/
https://ncbi.nlm.nih.gov/pubmed/22558403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036244
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