Proteasome Inhibition Can Impair Caspase-8 Activation upon Submaximal Stimulation of Apoptotic Tumor Necrosis Factor-related Apoptosis Inducing Ligand (TRAIL) Signaling

Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) can induce extrinsic apoptosis, resulting in caspase-8 activation, but may also initiate transcription-dependent prosurvival signaling. Proteasome inhibitors were suggested to promote TRAIL signal transduction through the death-inducing...

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Autors principals: Laussmann, Maike A., Passante, Egle, Hellwig, Christian T., Tomiczek, Bartłomiej, Flanagan, Lorna, Prehn, Jochen H. M., Huber, Heinrich J., Rehm, Markus
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340270/
https://ncbi.nlm.nih.gov/pubmed/22408249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.304378
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