Constitutively Active Mutant gp130 Receptor Protein from Inflammatory Hepatocellular Adenoma Is Inhibited by an Anti-gp130 Antibody That Specifically Neutralizes Interleukin 11 Signaling

Ligand-independent constitutively active gp130 mutants were described to be responsible for the development of inflammatory hepatocellular adenomas (IHCAs). These variants had gain-of-function somatic mutations within the extracellular domain 2 (D2) of the gp130 receptor chain. Cytokine-dependent Ba...

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Main Authors: Sommer, Jan, Effenberger, Timo, Volpi, Elena, Waetzig, Georg H., Bernhardt, Marten, Suthaus, Jan, Garbers, Christoph, Rose-John, Stefan, Floss, Doreen M., Scheller, Jürgen
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340202/
https://ncbi.nlm.nih.gov/pubmed/22523320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.349167
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