p21-activated Kinase 2 (PAK2) Inhibits TGF-β Signaling in Madin-Darby Canine Kidney (MDCK) Epithelial Cells by Interfering with the Receptor-Smad Interaction

TGF-β (transforming growth factor β) plays a variety of cellular functions mainly through the Smad pathway. Phosphorylation of the carboxyl SXS motif in R-Smads (Smad2 and Smad3) by the type I receptor TβRI is a key step for their activation. It has been reported that the serine/threonine kinase PAK...

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Bibliografiska uppgifter
Huvudupphovsmän: Yan, Xiaohua, Zhang, Junyu, Sun, Qinyu, Tuazon, Polygena T., Wu, Xiaoping, Traugh, Jolinda A., Chen, Ye-Guang
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2012
Ämnen:
Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340196/
https://ncbi.nlm.nih.gov/pubmed/22393057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.346221
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