FAPP2, cilium formation, and compartmentalization of the apical membrane in polarized Madin–Darby canine kidney (MDCK) cells

We have analyzed the role of the phosphatidylinositol-4-phosphate adaptor protein-2 (FAPP2), a component of the apical transport machinery, in cilium formation in polarized Madin–Darby canine kidney (MDCK) cells. We show that ciliogenesis is defective in FAPP2 knockdown cells. Furthermore, by using...

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Autori principali: Vieira, Otilia V., Gaus, Katharina, Verkade, Paul, Fullekrug, Joachim, Vaz, Winchil L. C., Simons, Kai
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2006
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1693701/
https://ncbi.nlm.nih.gov/pubmed/17116893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608291103
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