G Protein-regulated Inducer of Neurite Outgrowth (GRIN) Modulates Sprouty Protein Repression of Mitogen-activated Protein Kinase (MAPK) Activation by Growth Factor Stimulation

Gα(o/i) interacts directly with GRIN (G protein-regulated inducer of neurite outgrowth). Using the yeast two-hybrid system, we identified Sprouty2 as an interacting partner of GRIN. Gα(o) and Sprouty2 bind to overlapping regions of GRIN, thus competing for GRIN binding. Imaging experiments demonstra...

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Hlavní autoři: Hwangpo, Tracy Anh, Jordan, J. Dedrick, Premsrirut, Prem K., Jayamaran, Gomathi, Licht, Jonathan D., Iyengar, Ravi, Neves, Susana R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340172/
https://ncbi.nlm.nih.gov/pubmed/22383529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.320705
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