Methyl CpG-binding Protein Isoform MeCP2_e2 Is Dispensable for Rett Syndrome Phenotypes but Essential for Embryo Viability and Placenta Development

Methyl CpG-binding protein 2 gene (MeCP2) mutations are implicated in Rett syndrome (RTT), one of the common causes of female mental retardation. Two MeCP2 isoforms have been reported: MeCP2_e2 (splicing of all four exons) and MeCP2_e1 (alternative splicing of exons 1, 3, and 4). Their relative expr...

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Detaylı Bibliyografya
Asıl Yazarlar: Itoh, Masayuki, Tahimic, Candice G. T., Ide, Shuhei, Otsuki, Akihiro, Sasaoka, Toshikuni, Noguchi, Shigeru, Oshimura, Mitsuo, Goto, Yu-ichi, Kurimasa, Akihiro
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2012
Konular:
Molecular Bases of Disease
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340147/
https://ncbi.nlm.nih.gov/pubmed/22375006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.309864
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