Activation of Natural Killer T Cells Promotes M2 Macrophage Polarization in Adipose Tissue and Improves Systemic Glucose Tolerance via Interleukin-4 (IL-4)/STAT6 Protein Signaling Axis in Obesity

Natural killer T (NKT) cells are important therapeutic targets in various disease models and are under clinical trials for cancer patients. However, their function in obesity and type 2 diabetes remains unclear. Our data show that adipose tissues of both mice and humans contain a population of type...

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Autors principals: Ji, Yewei, Sun, Shengyi, Xu, Aimin, Bhargava, Prerna, Yang, Liu, Lam, Karen S. L., Gao, Bin, Lee, Chih-Hao, Kersten, Sander, Qi, Ling
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340139/
https://ncbi.nlm.nih.gov/pubmed/22396530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.350066
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