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Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein–Barr virus

Poly(ADP-ribose) polymerase (PARP) inhibitors can generate synthetic lethality in cancer cells defective in homologous recombination. However, the mechanism(s) by which they affect DNA repair has not been established. Here we directly determined the effects of PARP inhibition and PARP1 depletion on...

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Detalhes bibliográficos
Main Authors: Ma, Wenjian, Halweg, Christopher J., Menendez, Daniel, Resnick, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340099/
https://ncbi.nlm.nih.gov/pubmed/22493268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118078109
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