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Mechanistic insight into the blocking of CO diffusion in [NiFe]-hydrogenase mutants through multiscale simulation

[NiFe]-hydrogenases are fascinating biological catalysts with potential application in biofuel cells. However, a severe problem in practical application is the strong sensitivity of hydrogenase to gaseous inhibitor molecules such as CO and O(2). Recently, a number of successful protein engineering s...

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Détails bibliographiques
Auteurs principaux: Wang, Po-hung, Blumberger, Jochen
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340082/
https://ncbi.nlm.nih.gov/pubmed/22493222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1121176109
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