Targeted Gene Inactivation of Calpain-1 Suppresses Cortical Degeneration Due to Traumatic Brain Injury and Neuronal Apoptosis Induced by Oxidative Stress

Calpains are calcium-regulated cysteine proteases that have been implicated in the regulation of cell death pathways. Here, we used our calpain-1 null mouse model to evaluate the function of calpain-1 in neural degeneration following a rodent model of traumatic brain injury. In vivo, calpain-1 null...

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Detalhes bibliográficos
Main Authors: Yamada, Kaori H., Kozlowski, Dorothy A., Seidl, Stacey E., Lance, Steven, Wieschhaus, Adam J., Sundivakkam, Premanand, Tiruppathi, Chinnaswamy, Chishti, Imran, Herman, Ira M., Kuchay, Shafi M., Chishti, Athar H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339949/
https://ncbi.nlm.nih.gov/pubmed/22367208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.302612
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