CHFR Protein Regulates Mitotic Checkpoint by Targeting PARP-1 Protein for Ubiquitination and Degradation

The mitotic checkpoint gene CHFR (checkpoint with forkhead-associated (FHA) and RING finger domains) is silenced by promoter hypermethylation or mutated in various human cancers, suggesting that CHFR is an important tumor suppressor. Recent studies have reported that CHFR functions as an E3 ubiquiti...

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Hlavní autoři: Kashima, Lisa, Idogawa, Masashi, Mita, Hiroaki, Shitashige, Miki, Yamada, Tesshi, Ogi, Kazuhiro, Suzuki, Hiromu, Toyota, Minoru, Ariga, Hiroyoshi, Sasaki, Yasushi, Tokino, Takashi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339944/
https://ncbi.nlm.nih.gov/pubmed/22337872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.321828
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