Unique cellular and mitochondrial defects mediate FK506-induced islet β-cell dysfunction

OBJECTIVE: Determine biological mechanisms involved in post transplantation diabetes mellitus caused by the immunosuppressant FK506. METHODS: INS-1 cells and isolated rat islets were incubated with vehicle or FK506 and harvested at 24 hr intervals. Cells were assessed for viability, apoptosis, proli...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Rostambeigi, Nassir, Lanza, Ian R., Dzeja, Petras, Deeds, Michael C., Irving, Brian A., Reddi, Honey V., Madde, Pranathi, Zhang, Song, Asmann, Yan W., Anderson, Jarett M., Schimke, Jill M., Nair, K. S., Eberhardt, Norman L., Kudva, Yogish C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339767/
https://ncbi.nlm.nih.gov/pubmed/21200364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0b013e3182094a33
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