Unique cellular and mitochondrial defects mediate FK506-induced islet β-cell dysfunction

OBJECTIVE: Determine biological mechanisms involved in post transplantation diabetes mellitus caused by the immunosuppressant FK506. METHODS: INS-1 cells and isolated rat islets were incubated with vehicle or FK506 and harvested at 24 hr intervals. Cells were assessed for viability, apoptosis, proli...

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Main Authors: Rostambeigi, Nassir, Lanza, Ian R., Dzeja, Petras, Deeds, Michael C., Irving, Brian A., Reddi, Honey V., Madde, Pranathi, Zhang, Song, Asmann, Yan W., Anderson, Jarett M., Schimke, Jill M., Nair, K. S., Eberhardt, Norman L., Kudva, Yogish C.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339767/
https://ncbi.nlm.nih.gov/pubmed/21200364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0b013e3182094a33
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