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The structure of the kinesin-1 motor-tail complex reveals the mechanism of autoinhibition
When not transporting cargo, kinesin-1 is autoinhibited by binding of a tail region to the motor domains, but the mechanism of inhibition is unclear. We report the crystal structure of a motor domain dimer in complex with its tail domain at 2.2 Å and compare it with a structure of the motor domain a...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3339660/ https://ncbi.nlm.nih.gov/pubmed/21836017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1204824 |
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