Preferential accumulation of amyloid-beta in presynaptic glutamatergic terminals (VGluT1 and VGluT2) in Alzheimer’s disease cortex

Amyloid-beta (Aβ) is thought to play a central role in synaptic dysfunction (e.g. neurotransmitter release) and synapse loss. Glutamatergic dysfunction is involved in the pathology of Alzheimer’s disease (AD) and perhaps plays a central role in age-related cognitive impairment. Yet, it is largely un...

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Autors principals: Sokolow, Sophie, Luu, Sanh H., Nandy, Karabi, Miller, Carol A., Vinters, Harry V., Poon, Wayne W., Gylys, Karen H.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339276/
https://ncbi.nlm.nih.gov/pubmed/21914482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2011.08.027
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