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Metabolically induced heteroplasmy shifting and L-arginine treatment reduce the energetic defect in a neuronal-like model of MELAS
The m.3243A>G variant in the mitochondrial tRNA(Leu (UUR)) gene is a common mitochondrial DNA (mtDNA) mutation. Phenotypic manifestations depend mainly on the heteroplasmy, i.e. the ratio of mutant to normal mtDNA copies. A high percentage of mutant mtDNA is associated with a severe, life-threate...
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Main Authors: | , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3339237/ https://ncbi.nlm.nih.gov/pubmed/22306605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2012.01.010 |
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