Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma

Fbxw7α is a member of the F-box family of proteins, which function as the substrate-targeting subunits of SCF (Skp1/Cul1/F-box protein) ubiquitin ligase complexes. Using differential purifications and mass spectrometry, we identified p100, an inhibitor of NF-κB signalling, as an interactor of Fbxw7α...

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Main Authors: Busino, Luca, Millman, Scott E., Scotto, Luigi, Kyratsous, Christos A., Basrur, Venkatesha, O’Connor, Owen, Hoffmann, Alexander, Elenitoba-Johnson, Kojo S., Pagano, Michele
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339029/
https://ncbi.nlm.nih.gov/pubmed/22388891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2463
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