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Early structural features in mammalian prion conformation conversion
The conversion to a disease-associated conformer (PrP(Sc)) of the cellular prion protein (PrP(C)) is the central event in prion diseases. Wild-type PrP(C) converts to PrP(Sc) in the sporadic forms of the disorders through an unknown mechanism. These forms account for up to 85% of all human (Hu) occu...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Landes Bioscience
2012
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3338963/ https://ncbi.nlm.nih.gov/pubmed/22453176 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.6.1.18425 |
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