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Two-steps control of cellular prion physiology by the extracellular regulated kinase-1 (ERK1)
Cellular prion (PrP(C)) undergoes a regulated α-secretase-like cleavage by the disintegrin ADAM17 similar to the one taking place on β-Amyloid Precursor Protein (βAPP). Because these cleavages give rise to biologically active fragments, understanding their regulation could be of importance. We have...
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| Natura: | Artigo |
| Lingua: | Inglês |
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Landes Bioscience
2012
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3338960/ https://ncbi.nlm.nih.gov/pubmed/22453173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.6.1.18004 |
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