Peripheral immunization induces functional intrahepatic Hepatitis C specific immunity following selective retention of vaccine-specific CD8 T cells by the liver: Immunization induced intrahepatic HCV-specific immunity

It is believed that an effective HCV vaccine must induce strong HCV-specific cytotoxic IFNγ(+) CD8(+) T cells able to migrate into and become fully activated within the liver, an organ known to suppress T-cell responses and induce tolerance. Given the importance of intrahepatic HCV-specific T cells...

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Autori principali: Lang Kuhs, Krystle A, Toporovski, Roberta, Ginsberg, Arielle A, Olsen, Abby L, Shedlock, Devon J, Morrow, Matthew P, Yan, Jian, Wells, Rebecca G, Weiner, David B
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2011
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338931/
https://ncbi.nlm.nih.gov/pubmed/22108033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/hv.7.12.18279
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