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The Novel Endocrine Disruptor Tolylfluanid Impairs Insulin Signaling in Primary Rodent and Human Adipocytes through a Reduction in Insulin Receptor Substrate-1 Levels

Emerging data suggest that environmental endocrine disrupting chemicals (EDCs) may contribute to the pathophysiology of obesity and diabetes. In prior work, the phenylsulfamide fungicide tolylfluanid (TF) was shown to augment adipocyte differentiation, yet its effects on mature adipocyte metabolism...

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Main Authors: Sargis, Robert M., Neel, Brian A., Brock, Clifton O., Lin, Yuxi, Hickey, Allison T., Carlton, Daniel A., Brady, Matthew J.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338892/
https://ncbi.nlm.nih.gov/pubmed/22387882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2012.02.015
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