A Small Molecule SMAC Mimic LBW242 Potentiates TRAIL- and Anticancer Drug-Mediated Cell Death of Ovarian Cancer Cells

BACKGROUND: Ovarian cancer remains a leading cause of death in women and development of new therapies is essential. Second mitochondria derived activator of caspase (SMAC) has been described to sensitize for apoptosis. We have explored the pro-apoptotic activity of LBW242, a mimic of SMAC/DIABLO, on...

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Main Authors: Petrucci, Eleonora, Pasquini, Luca, Bernabei, Manuela, Saulle, Ernestina, Biffoni, Mauro, Accarpio, Fabio, Sibio, Simone, Di Giorgio, Angelo, Di Donato, Violante, Casorelli, Assunta, Benedetti-Panici, Pierluigi, Testa, Ugo
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2012
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338831/
https://ncbi.nlm.nih.gov/pubmed/22558117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035073
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