A Small Molecule SMAC Mimic LBW242 Potentiates TRAIL- and Anticancer Drug-Mediated Cell Death of Ovarian Cancer Cells

BACKGROUND: Ovarian cancer remains a leading cause of death in women and development of new therapies is essential. Second mitochondria derived activator of caspase (SMAC) has been described to sensitize for apoptosis. We have explored the pro-apoptotic activity of LBW242, a mimic of SMAC/DIABLO, on...

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Detalhes bibliográficos
Main Authors: Petrucci, Eleonora, Pasquini, Luca, Bernabei, Manuela, Saulle, Ernestina, Biffoni, Mauro, Accarpio, Fabio, Sibio, Simone, Di Giorgio, Angelo, Di Donato, Violante, Casorelli, Assunta, Benedetti-Panici, Pierluigi, Testa, Ugo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338831/
https://ncbi.nlm.nih.gov/pubmed/22558117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035073
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