Effect of Synthetic Aβ Peptide Oligomers and Fluorinated Solvents on Kv1.3 Channel Properties and Membrane Conductance

The impact of synthetic amyloid β (1–42) (Aβ(1–42)) oligomers on biophysical properties of voltage-gated potassium channels Kv 1.3 and lipid bilayer membranes (BLMs) was quantified for protocols using hexafluoroisopropanol (HFIP) or sodium hydroxide (NaOH) as solvents prior to initiating the oligome...

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Detalhes bibliográficos
Main Authors: Lioudyno, Maria I., Broccio, Matteo, Sokolov, Yuri, Rasool, Suhail, Wu, Jessica, Alkire, Michael T., Liu, Virginia, Kozak, J. Ashot, Dennison, Philip R., Glabe, Charles G., Lösche, Mathias, Hall, James E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338507/
https://ncbi.nlm.nih.gov/pubmed/22563377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035090
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