Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells

Histone methylation is thought to be important for regulating Ag-driven T-cell responses. However, little is known about the effect of modulating histone methylation on inflammatory T-cell responses. We demonstrate that in vivo administration of the histone methylation inhibitor 3-deazaneplanocin A...

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Detalhes bibliográficos
Main Authors: He, Shan, Wang, Jina, Kato, Koji, Xie, Fang, Varambally, Sooryanarayana, Mineishi, Shin, Kuick, Rork, Mochizuki, Kazuhiro, Liu, Yongnian, Nieves, Evelyn, Mani, Ram-Shankar, Chinnaiyan, Arul M., Marquez, Victor E., Zhang, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338164/
https://ncbi.nlm.nih.gov/pubmed/22117046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-364422
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