AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progression

Reactivation of the androgen receptor (AR) during androgen depletion therapy (ADT) underlies castration-resistant prostate cancer (CRPCa). Alternative splicing of the AR gene and synthesis of constitutively-active COOH-terminally truncated AR variants lacking the AR ligand binding domain has emerged...

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Detalhes bibliográficos
Main Authors: Li, Yingming, Hwang, Tae Hyun, Oseth, LeAnn, Hauge, Adam, Vessella, Robert L., Schmechel, Stephen C., Hirsch, Betsy, Beckman, Kenneth B., Silverstein, Kevin A., Dehm, Scott M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3337879/
https://ncbi.nlm.nih.gov/pubmed/22266865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.637
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