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AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progression
Reactivation of the androgen receptor (AR) during androgen depletion therapy (ADT) underlies castration-resistant prostate cancer (CRPCa). Alternative splicing of the AR gene and synthesis of constitutively-active COOH-terminally truncated AR variants lacking the AR ligand binding domain has emerged...
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| Asıl Yazarlar: | , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2012
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3337879/ https://ncbi.nlm.nih.gov/pubmed/22266865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.637 |
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