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CTCF-dependent chromatin insulator as a built-in attenuator of angiogenesis
VEGF is a pivotal pro-angiogenic growth factor and its dosage decisively impacts vascularization. We recently identified a CTCF-dependent chromatin insulator that critically restrains the transcriptional induction of VEGF and angiogenesis. We postulate that CTCF may exert enhancer blocking by mediat...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Landes Bioscience
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3337828/ https://ncbi.nlm.nih.gov/pubmed/22414750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/trns.19634 |
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