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Promyelocytic leukemia nuclear bodies support a late step in DNA double-strand break repair by homologous recombination
The PML protein and PML nuclear bodies (PML-NB) are implicated in multiple cellular functions relevant to tumor suppression, including DNA damage response. In most cases of acute promyelocytic leukemia, the PML and retinoic acid receptor alpha (RARA) genes are translocated, resulting in expression o...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3337353/ https://ncbi.nlm.nih.gov/pubmed/22213200 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.24050 |
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