The micro-RNA 199b-5p regulatory circuit involves Hes1, CD15, and epigenetic modifications in medulloblastoma

Micro-RNA (miR) 199b-5p targets Hes1 in medulloblastoma, one of the downstream effectors of both the canonical Notch and noncanonical Sonic Hedgehog pathways. In medulloblastoma patients, expression of miR-199b-5p is significantly decreased in metastatic cases, thus suggesting a downregulation mecha...

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Autors principals: Andolfo, Immacolata, Liguori, Lucia, De Antonellis, Pasqualino, Cusanelli, Emilio, Marinaro, Federica, Pistollato, Francesca, Garzia, Livia, De Vita, Gennaro, Petrosino, Giuseppe, Accordi, Benedetta, Migliorati, Roberta, Basso, Giuseppe, Iolascon, Achille, Cinalli, Giuseppe, Zollo, Massimo
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2012
Matèries:
Basic and Translational Investigations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3337299/
https://ncbi.nlm.nih.gov/pubmed/22411914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos002
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