MiR-34a Targeting of Notch Ligand Delta-Like 1 Impairs CD15(+)/CD133(+) Tumor-Propagating Cells and Supports Neural Differentiation in Medulloblastoma

BACKGROUND: Through negative regulation of gene expression, microRNAs (miRNAs) can function as oncosuppressors in cancers, and can themselves show altered expression in various tumor types. Here, we have investigated medulloblastoma tumors (MBs), which arise from an early impairment of developmental...

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Detalhes bibliográficos
Main Authors: de Antonellis, Pasqualino, Medaglia, Chiara, Cusanelli, Emilio, Andolfo, Immacolata, Liguori, Lucia, De Vita, Gennaro, Carotenuto, Marianeve, Bello, Annamaria, Formiggini, Fabio, Galeone, Aldo, De Rosa, Giuseppe, Virgilio, Antonella, Scognamiglio, Immacolata, Sciro, Manuela, Basso, Giuseppe, Schulte, Johannes H., Cinalli, Giuseppe, Iolascon, Achille, Zollo, Massimo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171461/
https://ncbi.nlm.nih.gov/pubmed/21931765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024584
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