Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice

Liver X receptors (LXRα and LXRβ) are important regulators of cholesterol and lipid metabolism, and their activation has been shown to inhibit cardiovascular disease and reduce atherosclerosis in animal models. Small molecule agonists of LXR activity are therefore of great therapeutic interest. Howe...

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Detalhes bibliográficos
Principais autores: Zhang, Yuan, Breevoort, Sarah R., Angdisen, Jerry, Fu, Mingui, Schmidt, Daniel R., Holmstrom, Sam R., Kliewer, Steven A., Mangelsdorf, David J., Schulman, Ira G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336978/
https://ncbi.nlm.nih.gov/pubmed/22484817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59817
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