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Hypophysitis Induced by Monoclonal Antibodies to Cytotoxic T Lymphocyte Antigen 4: Challenges from a New Cause of a Rare Disease

Specific human monoclonal antibodies antagonize cytotoxic T-lymphocyte antigen 4 (anti–CTLA-4 mAbs), a negative regulator of the immune system, inducing unrestrained T-cell activation. In patients with advanced or metastatic melanoma, one of these agents, ipilimumab, produced considerable disease co...

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Detalhes bibliográficos
Main Authors: Torino, Francesco, Barnabei, Agnese, De Vecchis, Liana, Salvatori, Roberto, Corsello, Salvatore M.
Formato: Artigo
Idioma:Inglês
Publicado em: AlphaMed Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336822/
https://ncbi.nlm.nih.gov/pubmed/22477725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2011-0404
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