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The monoclonal antibody to cytotoxic T lymphocyte antigen 4, ipilimumab, in the treatment of melanoma
BACKGROUND: Cytotoxic T lymphocyte antigen 4 (CTLA-4) is an inhibitory regulator of the T-cell immune response against tumor cells. Ipilimumab is a monoclonal antibody directed against CTLA-4. OBJECTIVE: This review describes the basic mechanism of ipilimumab and discusses data available to date wit...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Dove Medical Press
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3278204/ https://ncbi.nlm.nih.gov/pubmed/22346364 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CMAR.S15551 |
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