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Increased apoptosis in cancer cells in vitro and in vivo by ceramides in transferrin-modified liposomes
Lysosomes are a promising therapeutic target for induction apoptosis in cancer cells due to lysosomal membrane permeabilization (LMP) leading to leakage of hydrolytic enzymes, especially the cathepsins, into the cytoplasm. We hypothesized that with the modification of the ceramide-loaded liposomes w...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Landes Bioscience
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3335981/ https://ncbi.nlm.nih.gov/pubmed/22336588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.13.1.18871 |
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