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Increased promoter methylation of the immune regulatory gene SHP-1 in leukocytes of multiple sclerosis subjects
The protein tyrosine phosphatase, SHP-1, is a negative regulator of proinflammatory signaling and autoimmune disease. We have previously reported reduced SHP-1 expression in peripheral blood leukocytes of subjects with multiple sclerosis (MS). Recent evidence indicates that virus-induced DNA methyla...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3335962/ https://ncbi.nlm.nih.gov/pubmed/22458980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2012.03.003 |
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