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Increased promoter methylation of the immune regulatory gene SHP-1 in leukocytes of multiple sclerosis subjects

The protein tyrosine phosphatase, SHP-1, is a negative regulator of proinflammatory signaling and autoimmune disease. We have previously reported reduced SHP-1 expression in peripheral blood leukocytes of subjects with multiple sclerosis (MS). Recent evidence indicates that virus-induced DNA methyla...

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Detalhes bibliográficos
Main Authors: Kumagai, Chiharu, Kalman, Bernadette, Middleton, Frank A., Vyshkina, Tamara, Massa, Paul T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335962/
https://ncbi.nlm.nih.gov/pubmed/22458980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2012.03.003
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