Ranolazine stabilizes cardiac Ryanodine receptors: a novel mechanism for the suppression of Early afterdepolarization and Torsade de Pointes in Long QT type 2

BACKGROUND: Ranolazine (Ran) is known to inhibit multiple targets, including: the late Na(+) current, I(Na), the rapid delayed rectifying K(+) current I(Kr), L-type Ca(2+) current I(Ca,L), and fatty-acid metabolism. Functionally, Ran suppresses early afterdepolarization (EADs) and Torsade de Pointes...

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Hlavní autoři: Parikh, Ashish, Mantravadi, Rajkumar, Kozhevnikov, Dmitry, Roche, Michael A., Ye, Yanping, Owen, Laura J., Puglisi, Jose Luis, Abramson, Jonathan J., Salama, Guy
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335957/
https://ncbi.nlm.nih.gov/pubmed/22245792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2012.01.010
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