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Increased DNA methyltransferase activity and DNA methylation following epidermal growth factor stimulation in ovarian cancer cells

Ovarian cancer progression is correlated with accumulation of aberrant CpG island methylation. In ovarian cancer, ascites fluid contains numerous Epidermal-Growth-Factor-Receptor (EGFR) activators, which could result in a tumor microenvironment of constant EGFR activation. Signaling pathways downstr...

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Bibliografiske detaljer
Main Authors: Samudio-Ruiz, Sabrina L, Hudson, Laurie G
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335945/
https://ncbi.nlm.nih.gov/pubmed/22430797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.7.3.19273
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