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Increased DNA methyltransferase activity and DNA methylation following epidermal growth factor stimulation in ovarian cancer cells

Ovarian cancer progression is correlated with accumulation of aberrant CpG island methylation. In ovarian cancer, ascites fluid contains numerous Epidermal-Growth-Factor-Receptor (EGFR) activators, which could result in a tumor microenvironment of constant EGFR activation. Signaling pathways downstr...

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Detalhes bibliográficos
Main Authors: Samudio-Ruiz, Sabrina L, Hudson, Laurie G
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335945/
https://ncbi.nlm.nih.gov/pubmed/22430797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.7.3.19273
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