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Pharmacological induction of heme oxygenase-1 by a triterpenoid protects neurons against ischemic injury
BACKGROUND AND PURPOSE: Heme oxygenase-1 (HO-1) is an inducible phase-2 enzyme that degrades toxic heme; its role in cerebral ischemia is not fully understood. We hypothesize that chemically induced HO-1 upregulation with the novel triterpenoid CDDO-Im (2-cyano-3,12 dioxooleana-1,9 dien-28-oyl imida...
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| Autors principals: | , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3335928/ https://ncbi.nlm.nih.gov/pubmed/22461332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.111.647420 |
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