Pharmacological induction of heme oxygenase-1 by a triterpenoid protects neurons against ischemic injury

BACKGROUND AND PURPOSE: Heme oxygenase-1 (HO-1) is an inducible phase-2 enzyme that degrades toxic heme; its role in cerebral ischemia is not fully understood. We hypothesize that chemically induced HO-1 upregulation with the novel triterpenoid CDDO-Im (2-cyano-3,12 dioxooleana-1,9 dien-28-oyl imida...

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Main Authors: Zhang, Feng, Wang, Suping, Zhang, Meijuan, Weng, Zhongfang, Li, Peiying, Gan, Yu, Zhang, Lili, Cao, Guodong, Gao, Yanqin, Leak, Rehana K., Sporn, Michael B., Chen, Jun
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335928/
https://ncbi.nlm.nih.gov/pubmed/22461332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.111.647420
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