Cysteinyl leukotriene overproduction in aspirin-exacerbated respiratory disease is driven by platelet-adherent leukocytes

Cysteinyl leukotriene (cysLT) overproduction is a hallmark of aspirin-exacerbated respiratory disease (AERD), but its mechanism is poorly understood. Because adherent platelets can convert the leukocyte-derived precursor leukotriene (LT)A(4) to LTC(4), the parent cysLT, through the terminal enzyme L...

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Bibliographische Detailangaben
Hauptverfasser: Laidlaw, Tanya M., Kidder, Molly S., Bhattacharyya, Neil, Xing, Wei, Shen, Shiliang, Milne, Ginger L., Castells, Mariana C., Chhay, Heng, Boyce, Joshua A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2012
Schlagworte:
Phagocytes, Granulocytes, and Myelopoiesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335383/
https://ncbi.nlm.nih.gov/pubmed/22262771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-384826
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